Product description
Key Preassembled Glu-Gly Dipeptide for Semaglutide
Core Hydrophilic Dipeptide for Semaglutide Synthesis
Glu-Gly is a characteristic hydrophilic sequence in the Semaglutide backbone. The side-chain carboxyl group of glutamic acid plays an important role in peptide water solubility and in vivo dissolution performance.
This product provides the complete preassembled Glu-Gly dipeptide, enabling one-step incorporation onto the resin during peptide synthesis. Compared with sequential coupling of Glu and Gly monomers, it eliminates one coupling reaction, significantly reduces truncated impurities, improves the overall synthetic yield of Semaglutide API, and is well suited for large-scale industrial production.
Orthogonal Stepwise Deprotection Compatible with Standard Fmoc Workflows
The N-terminal Fmoc protecting group can be selectively removed under mild piperidine treatment without damaging the fully assembled peptide chain. The glutamic acid side-chain OtBu tert-butyl ester is removed only during the final TFA cleavage step, making the product fully compatible with mainstream Fmoc solid-phase peptide synthesis (SPPS) workflows. After deprotection, the native free Glu-Gly dipeptide is obtained and can be further coupled with additional amino acids to extend the complete GLP-1 peptide chain.
No Pharmacological or Cosmetic Activity
This intermediate contains a bulky hydrophobic Fmoc fluorenyl group and an OtBu tert-butyl ester protecting group, resulting in a molecular size too large to penetrate cell membranes or the skin barrier. It possesses no intrinsic biological activities such as glucose regulation, collagen stimulation, skin whitening, or soothing effects. Direct injection, oral administration, or topical application may leave residual fluorenyl or tert-butyl degradation impurities, potentially causing skin or mucosal irritation. Therefore, it is not intended for pharmaceutical formulations or cosmetic applications.
Universal Preassembled Building Block for Acidic Amino Acid Sequences
In addition to Semaglutide, this intermediate can be used in the industrial synthesis of other hydrophilic GLP peptides containing glutamic acid or aspartic acid residues, as well as moisturizing cosmetic peptides. The preassembled Glu-Gly fragment addresses the challenges of low coupling efficiency and high impurity formation associated with stepwise coupling of acidic amino acid sequences, significantly reducing purification complexity and production costs.
This product is supplied exclusively as an industrial intermediate for pharmaceutical API synthesis. It is intended solely for peptide synthesis during pharmaceutical manufacturing and is not suitable for direct injection, oral administration, or topical application.