Shanghai Yuli Biotechnology CO.,LTD.
Acetyl Hydroxyproline

CAS: 33996-33-7

Purpose: Provides anti-aging, skin barrier-enhancing, anti-fibrotic, and anti-inflammatory benefits.

Formula: C7H11NO4

Acetyl Hydroxyproline
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Product description
This advanced cosmetic peptide ingredient promotes the synthesis of type I and type III collagen while inhibiting matrix metalloproteinases (MMPs), reducing collagen degradation and preserving dermal integrity. By strengthening the skin's supportive extracellular matrix, it helps diminish fine dehydration lines, nasolabial folds, and crow's feet, while improving skin laxity, enlarged pores caused by loss of firmness, and the appearance of early stretch marks.
The ingredient significantly enhances skin barrier function by upregulating ceramide biosynthesis through activation of the SPTLC1 gene. Increased ceramide production reinforces intercellular lipid organization and epidermal tight junctions, substantially reducing transepidermal water loss (TEWL). It delivers long-lasting hydration while improving dryness, flaking, dehydration, and seasonal skin tightness. Human studies have demonstrated enhanced barrier stability and reduced dryness-related discomfort after four weeks of continuous use, making it particularly suitable for dry, sensitive, and mildly eczema-prone skin.
Its potent anti-glycation activity inhibits the formation of advanced glycation end products (AGEs), helping prevent collagen cross-linking, loss of elasticity, and dull, yellow-toned skin associated with glycation. By scavenging reactive carbonyl intermediates, it complements ingredients such as carnosine to establish a comprehensive anti-glycation strategy, improving skin radiance affected by excessive sugar intake, sleep deprivation, and photoaging.
The ingredient also provides broad-spectrum antioxidant and anti-inflammatory protection by neutralizing reactive oxygen species (ROS) generated by UV exposure and blue light, protecting fibroblast DNA against oxidative stress. It downregulates inflammatory cytokines including IL-6 and TNF-α while reducing the release of itch-associated mediators, rapidly relieving burning, irritation, and itching caused by dryness or barrier impairment. It is well suited for post-procedure skincare and formulations used after chemical peels to minimize irritation and excessive desquamation.
Designed for excellent skin compatibility, the ingredient is free of acids and irritating functional groups, with a low sensitization profile confirmed by patch testing. It is suitable for long-term use on delicate skin, including the eye area and skin during pregnancy, without dependency or rebound effects after discontinuation. In addition, it provides a smooth, moisturizing skin feel while reducing the dryness commonly associated with high-performance cosmetic formulations.
Manufactured under standardized GMP-compliant cleanroom conditions, the ingredient is supplied with complete quality control and regulatory documentation. It is suitable for the development of anti-aging, skin barrier repair, soothing, and brightening cosmetic formulations.
This product is intended solely as a cosmetic ingredient for external use. It is not intended for oral administration or subcutaneous injection.
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