Shanghai Yuli Biotechnology CO.,LTD.
Acetyl Tetrapeptide-5

CAS: 820959-17-9

Purpose: Helps reduce under-eye puffiness while improving skin elasticity and overall smoothness.

Formula: C20H28N8O7

Acetyl Tetrapeptide-5
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Product description
This cosmetic-grade peptide ingredient reduces under-eye puffiness by inhibiting angiotensin-converting enzyme (ACE-1), decreasing vascular permeability through a well-defined biological pathway. By competitively inhibiting ACE-1, it reduces the formation of angiotensin II, constricts microvessels, minimizes capillary leakage, and limits fluid accumulation in the periorbital area. At the same time, it promotes lymphatic drainage to eliminate excess interstitial fluid. In clinical evaluation, more than 70% of participants showed over 30% reduction in under-eye puffiness after 15 days, while visible improvement in eye bag volume was observed after 60 days, particularly for morning edema.
The ingredient improves periorbital microcirculation and visibly reduces vascular dark circles by strengthening the integrity of microvascular walls, reducing blood leakage and hemosiderin deposition, and accelerating local blood circulation. It effectively targets bluish and brownish dark circles associated with sleep deprivation and poor circulation. When combined with acetyl-L-carnitine, skin-brightening performance can be further enhanced.
It also provides potent anti-glycation activity by inhibiting the non-enzymatic glycation of skin proteins and reducing the formation of advanced glycation end products (AGEs). This helps prevent collagen and elastin cross-linking, preserves skin elasticity, and improves sagging eyelids, fine lines, and loss of firmness caused by glycation.
With broad-spectrum antioxidant properties, the ingredient scavenges reactive oxygen species (ROS) generated by UV exposure, blue light, and oxidative stress, protecting delicate periorbital keratinocytes and fibroblasts. It helps reduce dullness, roughness, oxidative damage, photoaging, and microvascular fragility around the eyes.
Designed specifically for the delicate eye area, it is free of hormones, does not induce muscle paralysis, and is non-photosensitizing. Patch testing has demonstrated excellent skin compatibility with very low irritation potential, making it suitable for long-term morning and evening use on thin and sensitive periorbital skin without dependency or rebound puffiness after discontinuation.
Manufactured under standardized GMP-compliant cleanroom conditions, the ingredient is supplied with a complete set of quality control and regulatory documentation. It is suitable for the development of cosmetic formulations targeting under-eye puffiness, dark circles, anti-glycation, and skin-firming applications.
This product is intended solely as a cosmetic ingredient for external use. It is not intended for oral administration or subcutaneous injection.
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